Research progress of resveratrol pharmacy

Resveratrol is extensive in seed plants and it is a phytoalexin. There are at least 12 families and 31 genera, 72 species which can discovered it. The main plants with abundant resveratrol are grapes, peanuts and Chinese medication polygonum cuspidatum, in particular the highest material of the fresh grape skins is 50 ~ 100 1/4 g with a dominant position anti-g-style. The studies have revealed that resveratrol has a range of pharmacological impacts of anti-tumor, anti cardiovascular disease, anti inflammatory, anti oxidation, liver and nerve system defense. It has actually become the natural active component that scientists connect excellent significance to. It has excellent medical value and market outlook.In the origin of cancer, promo and developing stage, the inhibition makes resveratrol end up being a hot research topic in cancer chemoprevention and chemotherapy. That resveratrol is mainly through inhibition of cytochrome enzymes, induction of cleansing enzymes, inhibition of cyclooxygenase, inhibition of protein kinase, and annoyed the role of estrogen and anti-tumor. Hormonal agent receptor, promoting tumor cell distinction and apoptosis path to inhibit tumor cell proliferation. The study revealed that resveratrol can inhibit the growth of human oral squamous cell cancer, human leukemia, human colon cancer, human breast carcinoma, prostate cancer and other cancer cells.Resveratrol considerably induced apoptosis of human gallbladder cancer cells, cell cycle circulation changes, generally for the percentage of G2/ M phase cells decreased S stage cells increased. Resveratrol and chia seed anti-leukocyte caused leukocyte differentiation apoptosis and cell cycle remain in the S stage. A growing number of scholars think that resveratrol is the primary function of elements plays cardiovascular protective impacts of red white wine. The study confirmed that resveratrol trans resveratrol, that the cardiovascular protective effects of polyphenols than red white wine have a more powerful. Thrombosis is the primary factor of myocardial infarction and stroke.Resveratrol has excellent anti-inflammatory results on acute and chronic inflammation.

The anti-inflammatory mechanism might be associated with inhibition of leukocyte migration, reduce leak, scavenging oxygen complimentary radicals, inhibit lipid peroxidation, and interfere with the metabolism of arachidonic acid to minimize the generation of inflammatory elements. Resveratrol on the lipoxygenase metabolism of arachidonic acid cyclooxygenase 2 metabolic paths are hindered. It can be lowered metabolites of leukotriene and prostaglandin generation on COX-2 selective inhibitions.Polyhydroxy stilbene product primarily has antioxidant and anti free radical roles. Research studies have shown that resveratrol has antioxidant, anti-free radical and the medicinal effects of the arachidonic acid metabolic process. It likewise has a crucial system of docetaxel several biological effects, such as anti growth, cardiovascular security, tissue organ damage, liver, shock prevention and care anti and so on. The health of biological and medicinal activity make resveratrol commonly used in medication, health items, cosmetics and food additives. Its functions in the treatment and prevention of cancer, cardiovascular and cerebrovascular illness, dementia, viral hepatitis , inflammatory diseases get a growing number of awareness. It has abroad clinical application possibility. It is expected to end up being a brand-new drug for avoidance and treatment of lots of diseasess.Source: http://www.cospcn.com

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